期刊论文

Effects of Lingyangjiao （Antelope horn） and Gouteng （Uncaria） on H2S Expression in Rats with Febrile Seizures

中文

中医药导报

1672-951X

2018

24

3

33-35

10.13862/j.cnki.cn43-1446/r.2018.03.009

湖南省科技计划项目（2015JC3076）； 湖南省教育厅青年科学基金项目（16B195）；

本校为第一机构

目的：探讨羚羊角与钩藤药对对发育期高热惊厥大鼠H2S表达的影响。方法：筛选50只大鼠随机分为空白组、模型组、羚角组、钩藤组、羚羊角-钩藤组,每组10只,各药物组大鼠按10 m L/kg给予相应药液,空白组给予等容积蒸馏水,1次/d,连续21 d。给药60 min后,置于（45±0.5）℃恒温水浴箱热水浴实验,隔日1次,连续10次,末次给药24 h后,水合氯醛麻醉,经下腔静脉留取静脉血,离心,取血浆,-80℃冰箱保存,测H2S含量。并取海马组织进行尼氏染色,观察病理变化。结果：羚羊角-钩藤组、羚羊角组及钩藤组在高热惊厥发生后海马CA1区神经细胞病理损伤程度有所减轻,其中羚羊角-钩藤组减轻更明显,优于羚羊角组、钩藤组。...

Objective： To investigate the effect of Lingyangjiao（antelope horn） and Gouteng（uncaria） combined on the expression of H2 S in rats with febrile seizures. Methods： A total of 50 rats were randomly divided into model group, antelope horn group, uncaria group, antelope horn-uncaria group. The rats were given liquid medicine with 10 m L·kg-1 in each group, and the blank group was given the same volume of distilled water,once a day, for 21 days. After administration for 60 min, the rats were placed in（45±0.5） ℃ constant hot bath equipmen...