Insight into Crosstalk between Ferroptosis and Necroptosis: Novel Therapeutics in Ischemic Stroke

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成果类型：

期刊论文

作者：

Zhou, Yue;Liao, Jun;Mei, Zhigang;Liu, Xun;Ge, Jinwen

作者机构：

[Ge, Jinwen; Mei, Zhigang; Zhou, Yue; Liu, Xun] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

[Liao, Jun] Hunan Univ Chinese Med, Med Sch, Changsha 410208, Hunan, Peoples R China.

[Mei, Zhigang] China Three Gorges Univ, Med Coll, Third Grade Pharmacol Lab Chinese Med Approved St, Yichang 443002, Hubei, Peoples R China.

[Ge, Jinwen] Shaoyang Univ, Sch Med, Shaoyang 422000, Hunan, Peoples R China.

语种：

英文

期刊：

Oxidative Medicine and Cellular Longevity

ISSN：

1942-0900

年：

2021

卷：

2021

DOI：

10.1155/2021/9991001

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81774033, 81774174]; Key Projects of Hunan Province Education Department [20A366]; fund for Youth Top Talent Project of Health and Family Planning Commission of Hubei Province [EWT-2019-48]

机构署名：

本校为第一机构

院系归属：

医学院

中西医结合学院

摘要：

Ferroptosis is a nonapoptotic form of cell death characterized by iron-dependent accumulation of lipid hydroperoxides to lethal levels. Necroptosis, an alternative form of programmed necrosis, is regulated by receptor-interacting protein (RIP) 1 activation and by RIP3 and mixed-lineage kinase domain-like (MLKL) phosphorylation. Ferroptosis and necroptosis both play important roles in the pathological progress in ischemic stroke, which is a complex brain disease regulated by several cell death pathways. In the past few years, increasing evidence has suggested that the crosstalk occurs between n...

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Insight into Crosstalk between Ferroptosis and Necroptosis: Novel Therapeutics in Ischemic Stroke

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