Tetrahydroxy stilbene glycoside attenuates acetaminophen-induced hepatotoxicity by UHPLC-Q-TOF/MS-based metabolomics and multivariate data analysis

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成果类型：

期刊论文

作者：

Gao, Yan;Li, Jun-Tong;Li, Xiang;Li, Xun;Yang, Song-Wei;...

通讯作者：

Zhang, Lan

作者机构：

[Li, Lin; Zhang, Lan; Gao, Yan; Li, Xiang] Capital Med Univ, Dept Pharm,Beijing Inst Brain Disorders,Minist Ed, Natl Clin Res Ctr Geriatr Dis,Key Lab Neurodegene, Beijing Engn Res Ctr Nervous Syst Drugs,Xuanwu Ho, Beijing 100053, Peoples R China.

[Gao, Yan; Chen, Nai-Hong] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing, Peoples R China.

[Gao, Yan; Chen, Nai-Hong] Chinese Acad Med Sci & Peking Union Med Coll, Neurosci Ctr, Beijing, Peoples R China.

[Li, Jun-Tong] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, Guangzhou, Peoples R China.

[Li, Xun; Chen, Nai-Hong; Yang, Song-Wei] Hunan Univ Chinese Med, Coll Pharm, Changsha, Peoples R China.

通讯机构：

[Zhang, Lan] C

Capital Med Univ, Dept Pharm,Beijing Inst Brain Disorders,Minist Ed, Natl Clin Res Ctr Geriatr Dis,Key Lab Neurodegene, Beijing Engn Res Ctr Nervous Syst Drugs,Xuanwu Ho, Beijing 100053, Peoples R China.

语种：

英文

关键词：

acetaminophen;Luminex analysis;metabolomics;tetrahydroxy stilbene glycoside;UHPLC-Q-TOF/MS

期刊：

Journal of Cellular Physiology

ISSN：

0021-9541

年：

2021

卷：

236

期：

页码：

3832-3862

DOI：

10.1002/jcp.30127

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81874351, 81873026, 81730096]; Beijing Postdoctoral Research FoundationChina Postdoctoral Science Foundation [2020-ZZ-00 1]; National Major Science and Technology Special Project of Major New Drug Creation [2017zx0910001-002-044]; Capital Science and Technology Leading Talents [z191100006119017]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Tetrahydroxy stilbene glycoside (TSG) is a main active compound in Polygonum multiflorum. Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. It is considered to be safe within a therapeutic range, in case of acute intoxication hepatotoxicity occurs. This present study aims to observe TSG-provided alleviation on APAP-induced hepatoxicity in C57BL/6 mice. APAP performs extensive necrosis and dissolves nucleus suggesting liver damage from hepatic histopathology. Serum alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase analysis a...

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Tetrahydroxy stilbene glycoside attenuates acetaminophen-induced hepatotoxicity by UHPLC-Q-TOF/MS-based metabolomics and multivariate data analysis

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