Tetrahydroxy stilbene glycoside attenuates acetaminophen-induced hepatotoxicity by UHPLC-Q-TOF/MS-based metabolomics and multivariate data analysis

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成果类型：

期刊论文

作者：

Gao, Yan;Li, Jun-Tong;Li, Xiang;Li, Xun;Yang, Song-Wei;...

通讯作者：

Zhang, L

作者机构：

[Li, Lin; Zhang, Lan; Gao, Yan; Li, Xiang; Zhang, L] Capital Med Univ, Dept Pharm,Beijing Inst Brain Disorders,Minist Ed, Natl Clin Res Ctr Geriatr Dis,Key Lab Neurodegene, Beijing Engn Res Ctr Nervous Syst Drugs,Xuanwu Ho, Beijing 100053, Peoples R China.

[Gao, Yan; Chen, Nai-Hong] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing, Peoples R China.

[Gao, Yan; Chen, Nai-Hong] Chinese Acad Med Sci & Peking Union Med Coll, Neurosci Ctr, Beijing, Peoples R China.

[Li, Jun-Tong] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, Guangzhou, Peoples R China.

[Li, Xun; Chen, Nai-Hong; Yang, Song-Wei] Hunan Univ Chinese Med, Coll Pharm, Changsha, Peoples R China.

通讯机构：

[Zhang, L ] C

Capital Med Univ, Dept Pharm,Beijing Inst Brain Disorders,Minist Ed, Natl Clin Res Ctr Geriatr Dis,Key Lab Neurodegene, Beijing Engn Res Ctr Nervous Syst Drugs,Xuanwu Ho, Beijing 100053, Peoples R China.

语种：

英文

关键词：

acetaminophen;Luminex analysis;metabolomics;tetrahydroxy stilbene glycoside;UHPLC-Q-TOF/MS

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2021

卷：

236

期：

页码：

3832-3862

DOI：

10.1002/jcp.30127

基金类别：

This study was supported by grants from the National Natural Sciences Foundation of China (No. 81874351, 81873026, and 81730096), Beijing Postdoctoral Research Foundation (2020‐ZZ‐001), National Major Science and Technology Special Project of Major New Drug Creation (2017zx0910001‐002‐044), and Capital Science and Technology Leading Talents (z191100006119017).

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本校为其他机构

院系归属：

药学院

摘要：

Tetrahydroxy stilbene glycoside (TSG) is a main active compound in Polygonum multiflorum. Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. It is considered to be safe within a therapeutic range, in case of acute intoxication hepatotoxicity occurs. This present study aims to observe TSG-provided alleviation on APAP-induced hepatoxicity in C57BL/6 mice. APAP performs extensive necrosis and dissolves nucleus suggesting liver damage from hepatic histopathology. Serum alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase analysis a...

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Tetrahydroxy stilbene glycoside attenuates acetaminophen-induced hepatotoxicity by UHPLC-Q-TOF/MS-based metabolomics and multivariate data analysis

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