[Li, Ming; Liu, Wenbin; Li, Wei; Gao, Feng] Cent South Univ, Xiangya Hosp 3, Cell Transplantat & Gene Therapy Inst, Changsha 410013, Hunan, Peoples R China.

[Yang, Shuting; Gao, Feng] Cent South Univ, Dept Ultrasonog, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China.

[Zhou, Li] Cent South Univ, Dept Pathol, Xiangya Hosp, Changsha 410013, Hunan, Peoples R China.

[Li, Ming] Changsha Stomatol Hosp, Changsha 410004, Hunan, Peoples R China.

[Li, Ming] Hunan Univ Chinese Med, Sch Stomatol, Changsha 410208, Hunan, Peoples R China.

[Li, W ] C

Cent South Univ, Xiangya Hosp 3, Cell Transplantat & Gene Therapy Inst, Changsha 410013, Hunan, Peoples R China.

Cent South Univ, Dept Radiol, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China.

antineoplastic agent;cyclin D1;histone H3;messenger RNA;mitogen activated protein kinase;mitogen activated protein kinase 1;mitogen activated protein kinase 3;piperlongumine;protein c fos;protein kinase B;transcription factor AP 1;unclassified drug;Akt signaling;animal experiment;animal model;animal tissue;antineoplastic activity;Article;bioassay;cancer inhibition;cancer tissue;carcinogenesis;cell cycle;cell growth;colony formation;colorectal cancer;colorectal cancer cell line;controlled study;Cyclin D1 gene;down regulation;enzyme activation;enzyme inhibition;female;flow cytometry;gene overexpression;half life time;histone phosphorylation;human;human cell;human tissue;immunoblotting;immunofluorescence;immunohistochemistry;in vivo study;MAPK signaling;mouse;mouse model;nonhuman;protein degradation;protein expression;protein function;reverse transcription polymerase chain reaction;tissue level;transcription regulation;tumor xenograft;ubiquitination