Investigation of natural minerals for ulcerative colitis therapy

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成果类型：

期刊论文

作者：

Sun, Zhiya;Long, Mei;Liu, Xinxuan;Zhang, Yi;Li, Shunxiang;...

通讯作者：

Yang, HM

作者机构：

[Sun, Zhiya; Zhang, Yi; Yang, Huaming; Long, Mei] Cent South Univ, Ctr Mineral Mat, Sch Minerals Proc & Bioengn, Changsha 410083, Peoples R China.

[Sun, Zhiya; Zhang, Yi; Yang, Huaming; Long, Mei] Cent South Univ, Hunan Int Joint Lab Mineral Mat, Changsha 410083, Peoples R China.

[Liu, Xinxuan] Hunan Univ Chinese Med, Sci & Technol Innovat Ctr, Changsha 410208, Peoples R China.

[Zhang, Yi; Yang, Huaming] Cent South Univ, Key Lab Clay Mineral Funct Mat China Bldg Mat Ind, Changsha 410083, Peoples R China.

[Li, Shunxiang] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

通讯机构：

[Yang, HM ] C

Cent South Univ, Ctr Mineral Mat, Sch Minerals Proc & Bioengn, Changsha 410083, Peoples R China.

语种：

英文

关键词：

Drug;In vivo evaluation;Natural minerals;Therapy;Ulcerative colitis

期刊：

Applied Clay Science

ISSN：

0169-1317

年：

2020

卷：

186

页码：

105436

DOI：

10.1016/j.clay.2020.105436

基金类别：

This work was supported by the National Natural Science Foundation of China ( 41572036 ), the National Science Fund for Distinguished Young Scholars ( 51225403 ), the Strategic Priority Research Program of Central South University ( ZLXD2017005 ), the Hunan Provincial Science and Technology Project ( 2016RS2004 , 2015TP1006 , 2018WK4023 ), the Key R&D Program of Hunan Province ( 2017GK2251 ), the Changsha Science and Technology Project ( KC1702029 ), and the Hunan Provincial Co-Innovation Centre for the Clean and Efficient Utilization of Strategic Metal Mineral Resources ( 2014-405 ).

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Ulcerative colitis (UC) affects millions of people worldwide and is currently incurable. As such, there is an urgent need for effective drugs that will promote UC remission. This study investigated the therapeutic effects of five typical natural minerals on UC induced by dextran sulfate sodium (DSS): kaolinite (Kaol), halloysite (Hal), diatomite (Dia), montmorillonite (Mt), and palygorskite (Pal). These minerals were characterized by lamellar, tubular, columnar porous, and fibrous morphologies, as well as centered size distribution and negative...

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Investigation of natural minerals for ulcerative colitis therapy

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