期刊论文

Huang, Wei-Hua

英文

Journal of Pharmaceutical and Biomedical Analysis

0731-7085

2018

150

199-207

10.1016/j.jpba.2017.12.011

National Natural Scientific Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31400306]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2015JJ3156]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2015M570692]; fundamental research funds for the central universities of Central South University [1681-7608040003]

本校为其他机构

Saponins such as notoginsenosides and ginsenosides from Panax notoginseng are responsible for the herb's clinical applications. Unfortunately, there is poor oral bioavailability of saponins. However, gut microbiota can transform saponins to yield the metabolites that are potential bioactive substances. In this study, we aimed to characterize the metabolic profiles of P. notoginseng saponins (PNS) by incubating them with human gut microbiota. The notoginsenosides, ginsenosides and related metabolites were separated and identified using a highly sensitive and selective high-performance liquid ch...