Inhibition of AMP-activated protein kinase pathway sensitizes human leukemia K562 cells to nontoxic concentration of doxorubicin

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成果类型：

期刊论文

作者：

Zhu, Qun;Shen, Bo;Zhang, Boshao;Zhang, Wei;Chin, Steve H.;...

通讯作者：

Jin, Junfei

作者机构：

[Zhu, Qun] Nanjing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Nanjing 210011, Jiangsu, Peoples R China.

[Shen, Bo] Jiangsu Canc Hosp, Dept Med Oncol, Nanjing 210009, Jiangsu, Peoples R China.

[Zhang, Boshao] Univ Alabama, Dept Biostat, Birmingham, AL 35294 USA.

[Zhang, Wei] Southeast Univ, Sch Med, Dept Pathophysiol, Nanjing 210009, Jiangsu, Peoples R China.

[Chin, Steve H.] Med Univ S Carolina, Dept Med, Div Hematol & Oncol, Charleston, SC 29425 USA.

通讯机构：

[Jin, Junfei] U

Univ S China, Res Ctr Life Sci, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

AMP-activated protein kinase;Doxorubicin;Human leukemia K562 cell;Apoptosis;Cell death

期刊：

Molecular and Cellular Biochemistry

ISSN：

0300-8177

年：

2010

卷：

340

期：

1-2

页码：

275-281

DOI：

10.1007/s11010-010-0428-3

基金类别：

Nanjing Medical University [08NMUZ025]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30971170]

机构署名：

本校为其他机构

院系归属：

中医学院

药学院

摘要：

Doxorubicin (Dox) is a commonly used anthracycline in many antitumor regimens. The dose related Dox-induced cardiotoxicity often poses challenge in clinical practice, lowering its dose and administering it in combination with other compound is an option. In this study, we found that a nontoxic concentration of Dox at 34.5 nM (20 ng/ml) combined with Compound C, an inhibitor used in AMP-activated protein kinase (AMPK) pathway, could kill human leukemia K562 cells. Additionally, this study confirmed that the combined effect was related to the inh...

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Inhibition of AMP-activated protein kinase pathway sensitizes human leukemia K562 cells to nontoxic concentration of doxorubicin

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