期刊论文

中文

中国药物警戒

1672-8629

2019

16

5

277-280

10.3969/j.issn.1672-8629.2019.05.005

国家自然科学基金重点项目(81630100):基于临床病症的传统无毒中药肝毒性客观辨识及机制研究。

本校为第一机构

目的 分析银屑病用药相关肝损伤的人群特征和药物特征,为银屑病临床合理用药提供参考.方法 对2012年1月 ～2016年12月银屑病用药相关肝损伤的病例进行回顾性分析.结果 共收集到银屑病用药相关肝损伤病例155例,其中男性101例,女性54例(男性:女性=1.87:1);年龄范围为11～80岁,其中31～50岁年龄段占比为48.38％.120例(77.42％)患者用药史较为清晰,损肝药物单一,中药致肝损伤占32.5％,西药致肝损伤占67.5％;二者服药到肝损伤发生时间集中在30天内,中药服药到肝损伤发生的中位时间(16天)大于西药(10.5天);导致肝损伤的药物主要为阿维A、甲氨蝶呤、雷公藤多苷片等,其中西药以阿维A(38.27％)和甲氨蝶呤...

Objective To provide reference for rational medication of psoriasis by analyzing the demographic and drug characteristics of drug-induced liver injury for psoriasis treatment. Methods A retrospective study was performed in drug-induced liver injury cases associated with psoriasis between January 2012 and December 2016. Results A total of 155 DILI cases were collected, including 101 males and 54 females. The age range is 11 to 80 years and the age of31~50 accounted for 48.38%. 120 cases(77.42%) of patients had clear history of medication, DILI caused by the tradi tional Chinese medicines(TCM) a...