期刊论文

中文

实用心脑肺血管病杂志

1008-5971

2015

3

34-37

10.3969/j.issn.1008-5971.2015.03.11

湖南省科技厅科技项目（2013SK3214）；

本校为第一机构

目的：探讨桃叶珊瑚苷（ AU）对脑出血大鼠的神经保护作用及对肿瘤坏死因子α（ TNF-α）的影响。方法将90只健康SD大鼠随机分成假手术组、脑出血组、AU治疗组，每组30只。脑出血组及AU治疗组大鼠于尾壳核区注入自体非肝素抗凝动脉血，建立脑出血动物模型，假手术组于相同部位注入0.9%氯化钠溶液。造模成功后， AU治疗组于术后6 h给予AU腹腔注射，脑出血组在相同时间给予相同剂量0.9%氯化钠溶液腹腔注射。各组分别在造模后12 h、2 d、3 d、5 d、7 d取6只大鼠，参照Longa 5级评分法进行神经功能缺损评分、采用HE染色并计算血肿周围脑组织白细胞数目、采用免疫组化法检测血肿周围脑组织中TNF-α表...

Objective To explore the neuroprotective effect of Aucubin and its impact on TNF-αin rats with cerebral hemorrhage. Methods A total of 90 adult male Sprague-Dawley rats were selected and randomly divided into groups A,B and C,each of 30 cases. Rats of A group were given sham-operation and 0. 9% sodium chloride solution injection on tail putamen area,while rats of groups A and B given autologous non-heparin anticoagulation arterial blood injection on tail putamen area to establish animal model of cerebral hemorrhage. After 6 hours of surgery,ra...