期刊论文

中文

中国微生态学杂志

1005-376X

2015

27

2

151-155

10.13381/j.cnki.cjm.201502007

湖南省中医药科研计划资助（2011113） 湖南省科技计划项目（2011SK3101）

本校为第一机构

目的探讨中药左金丸对因束缚-水浸应激引起的大鼠应激性胃溃疡胃黏膜损伤的保护作用的影响,并初步探讨其作用机制。方法将60只健康SD雄性大鼠随机分为6组,即空白对照组、模型对照组、阳性对照组、左金丸低剂量组、左金丸中剂量组和左金丸高剂量组。连续灌胃给药5 d,末次给药后禁食不禁水24 h,采用"束缚-水浸"应激法制备大鼠应激性胃溃疡模型。造模成功后进行胃体形态学观察,测量胃液pH值,计算胃溃疡指数(UI),并用酶联免疫法检测血清中前列腺素E2(PGE2)的含量。结果(1)与空白对照组比较,模型对照组大鼠胃液pH值明显降低、胃黏膜损伤指数(UI)显著升高(P

Objective To study the effect and mechanism of Zuojin pills on experimental stress gastric ulcer,and discuss its mechanism. Methods 60 healthy male SD rats were randomly divided into 6 groups： control group,model group,three（ high-,medium- and low-dose） Zuojin pills groups,and positive control group. The drug was given with continuous lavage for 5 days,then water fasting for 24 hours after the last administration. Water immersion and restraint stress（ WRS） was used to induce the experimental models of stress ulcear. Gastric morphology obse...