期刊论文

Influence of QiweiBaizhupowder on the lactase activity in intestine of mice with diarrhea induced by antibiotics

中文

中国微生态学杂志

1005-376X

2018

30

10

1126-1129

10.13381/j.cnki.cjm.201810003

国家自然科学基金面上项目（81573951） 国家自然科学基金青年基金（81703985） 长沙市科技计划项目（kq1706057）

本校为第一机构

目的探讨七味白术散对抗生素所致腹泻小鼠肠道乳糖酶活性的影响,从肠道功能酶角度阐释七味白术散治疗抗生素所致腹泻的作用机制。方法将SPF级昆明小鼠分为正常组、自愈组和治疗组。采用硫酸庆大霉素和头孢拉定混合抗生素制备腹泻小鼠模型,造模成功后,自愈组和正常组给予无菌生理盐水,治疗组灌胃七味白术散,治疗4d。无菌条件下采集治疗前后各组小鼠肠道前、中、后段黏膜,使用ONPG法测定样品中乳糖酶活性。结果抗生素所致腹泻模型小鼠肠道黏膜乳糖酶活性降低,七味白术散治疗4d后,治疗组小鼠腹泻症状消失,肠道黏膜乳糖酶活性恢复且提高。结论抗生素可引起小鼠腹泻及肠道乳糖酶活性下降,七味白术散可...

Objective To explore the influence of Qiwei Baizhu powder on the activity of lactase in the intestine of mice with diarrhea induced by antibiotics,and elucidate its treatment mechanism in terms of functional enzyme.Methods SPF mice were divided into Normal,Self-healing and Treatment groups respectively.The diarrhea models were established by giving the mixtures of gentamycin sulfate and cefradine.The mice in Treatment group were given decoction of Qiwei Baizhu powder by gavage for 4 days,while those in the other two groups were given sterile water.Before and after the treatment,the mucosa of t...