Objective To explore the mechanism of curative effect of Simo decoction on spleen-deficiency constipation.Methods The experimental mouse were randomly divided into 3 groups:control group,model group with spleen-deficiency constipation,treatment group with Simo decoction.The mouse models of spleen-deficiency constipation were established through gavage feeding of the mice with senna decoction for 7 days followed by diet restriction for 8 days to induce hunger/satiety disorder,and then given Simo decoction (treatment group) or equivalent amount o...