期刊论文

Effect of Bao-he Pills on intestinal microorganisms and enzyme activity in mice with dyspepsia

中文

中国微生态学杂志

1005-376X

2019

31

7

763-767

10.13381/j.cnki.cjm.201907004

国家自然科学基金青年基金(81703985) 湖南中医药大学化学工程与技术一流学科建设项目.

本校为第一机构

目的探究保和丸对食积小鼠肠道微生物及酶活性的影响。方法将32只实验小鼠(雌雄各半)随机分为正常组(n=12)、食积组(n=10)和治疗组(n=10)。其中正常组喂食正常饲料,其余组喂食特制饲料。待食积组和治疗组中小鼠出现粪便干结,腹部膨隆胀满后,立即对治疗组按6.67 g/(kg·d)剂量灌胃0.28 g/mL的保和丸汤剂,正常组与食积组灌胃等量的蒸馏水。每天2次,每次0.35 mL,持续4 d。比较分析小鼠肠道微生物及肠道酶活性。结果肠道微生物方面,食积组能显著增加细菌、乳酸菌、双歧杆菌和大肠埃希菌的数目,与正常组相比差异有统计学意义(均P

ObjectiveTo explore the effect of Bao-he Pills on intestinal microorganisms and enzyme activity in mice with dyspepsia.MethodsThe experimental animals were randomly divided into control group(n=12), dyspepsia group(n=10) or treatment group(n=10).The control group was fed normal diet, and the other two groups were fed special diet.After dry stool and abdominal distension of mice in the dyspepsia group and treatment group, 0.28 g/mL of of Bao-he Pills decoction was given immediately through gavage at a dose of 6.67 g/(kg·d) to the treatment grou...