期刊论文

Effect of Qiwei Baizhu San on intestinal sucrase activity in mice with diarrhea

中文

中国微生态学杂志

1005-376X

2019

31

10

1130-1134

10.13381/j.cnki.cjm.201910003

国家自然科学基金(81573951) 湖南省教育厅项目(13B082) 方剂学湖南省重点学科。

本校为其他机构

目的 探究七味白术散对菌群失调腹泻小鼠肠道蔗糖酶活性的影响,为其临床应用提供依据.方法 将132只SPF级KM小鼠分为正常组、模型组、七味白术散组,每组44只,雌雄各半.采用硫酸庆大霉素和头孢拉定混合抗生素制备腹泻小鼠模型,造模成功后,七味白术散组给予七味白术散汤剂进行治疗,正常组和模型组给予等量无菌水进行灌胃,连续治疗6d.造模结束和治疗期间每天灌胃前进行小鼠肠道取材,分别测定小鼠肠道内容物、肠道黏膜前中后段蔗糖酶活性,观察治疗期间蔗糖酶活性的动态变化.结果 造模结束后,小鼠的肠道内容物和肠道黏膜前中后段蔗糖酶活性与正常组比均下降明显(t=23.684,P＜0.01).肠道内容物:治疗第1...

Objective To explore the activity of sucrase in the intestine of mice with dysbacteriosis diarrhea and provide reference for rational clinical application of Qiwei Baizhu San. Methods A total of 132 mice were randomly divided into normal group, model group, Qiwei Baizhu San (QBS) group or lactase group.All groups except the normal group were intragastrically administered antibiotics for 5 days to establish dysbacteriosis diarrhea models, then treated with Qiwei Baizhu San and lactase respectively.The normal group and model group were given the same amount of sterile water for 6 days.The intest...