期刊论文

Effect of Yangwei Sijunzi Tea on intestinal microorganisms, enzyme activity, and gastric motility in mice with spleen deficiency-type constipation

中文

中国微生态学杂志

1005-376X

2022

34

1

18-22+28

10.13381/j.cnki.cjm.202201004

中医方证研究转化医学湖南省重点实验室开放基金（2019FZ01）； 湖南中医药大学生物工程重点学科资助（校行科字[2018]3号）；

本校为第一机构

目的探讨养胃四君子茶对脾虚便秘小鼠肠道微生物及酶活性的影响。方法将40只小鼠随机分为正常对照组、模型组、治疗组[养胃四君子茶(低剂量组、中剂量组、高剂量组)],每组8只。对模型组和治疗组采用灌胃番泻叶水提液7 d后,改用饮食不节+缺水燥结+过度疲劳喂养8 d等方法。造模结束后,模型组和正常对照组采用无菌水灌胃,治疗组用养胃四君子茶灌胃,0.8 mL/d连续6 d。然后采集肠道内容物,分析肠道菌群及酶活性。结果与正常对照组小鼠肠道细菌总数比较,模型组显著上升(P0.05);大肠埃希菌数量各组差异无统计学意义(P>0.05);小鼠肠道乳酸菌数量养胃四君子茶低、中剂量组均较正常对照组、模型组显著升高...

ObjectiveTo observe the effect of Yangwei Sijunzi Tea on intestinal microorganisms and enzyme activity in mice with spleen deficiency-type constipation(SD-C.Methods40 mice were randomly divided into the model group, normal control group, or treatment groups of low-, medium-and high-dose of Yangwei Sijunzi Tea(YST, with 8 mice in each group.After intragastric administration of senna leaf water extract for 7 days, the model group was switched to treatment with improper diet+ lack of water and dryness+ excessive fatigue feeding for 8 days.After modeling, the normal control group was intragastrica...