期刊论文

中文

时珍国医国药

1008-0805

2010

21

9

2167-2170

10.3969/j.issn.1008-0805.2010.09.016

国家自然科学基金（No.30772696 No.30973717） 湖南省研究生创新基金（No.CX2009B168）

本校为其他机构

目的 探讨养心通脉有效部位方(active principle region of Yangxing Tongmai Formula,apr-YTF)促进急性心肌梗塞大鼠骨髓间充质干细胞(Mesenchymal stem cells,MSCs)定向归巢及其对心功能和病理的影响.方法 将造模成功的大鼠32只,随机分为apr-YTF组、香丹注射液组、重组人粒细胞集落刺激因子(rhG-CSF)组、模型对照组,每组8只,均于造模3 h后给予相应药物,连续5 d;均于造模后第2天开始腹腔注射5-溴脱氧尿嘧啶核苷(Brdu),连续4 d.用PcLab生物医学信号采集处理系统检测记录心功能,masson's三色染色检测梗塞心肌病理,Image-Pro Plus 6.0病理图象分析系统测量梗塞区瘢痕面积百分比,免疫组化的方法检测...

Objective To explore the effect of apr-YTF（active principle region of Yangxing Tongmai Formula）on cardiac function and pathology of MSCs homing to infarcted myocardium in rats.Methods32 SD male rats with acute myocardial infarction were randomly divided into apr-YTF group,Xiangdan injection group,recombinant human granulocyte colony stimulating factor（rhG-CSF）group and model control group 8 in each group.After 3 h,myocardial were given corresponding drug for 5 d.5-bromo-deoxyuridine（Brdu）was intrapthtoneally injected on day 2 after model ...