Objective To explore whether α7nAChR is involved in modulation of the immunological function in mice by 100 Hz EA. Methods NK cell activity was used as indicator of immunological function, splenic NK cell activity was measured by ,MTT method and immunofluoreseenee was adopted for the localization of α7nAChR in maerophage. Results Splenic NK cell activity in mice was obviously decreased following 100 Hz EA once a day for successive 3 days (P 〈 0.05 ) as α7nAChR could be detected on the surface of macrophage in mice. Furthermore, in vivo tr...