期刊论文

中文

时珍国医国药

1008-0805

2018

29

2

278-280

10.3969/j.issn.1008-0805.2018.02.008

国家自然科学基金

本校为第一机构

目的观察不同剂量活血药对(当归、川芎)、破血药对(三棱、莪术)对动脉粥样硬化(AS)小鼠主动脉血小板-白细胞C激酶底物(PLEK)、Polo样激酶3(PLK3)基因表达的影响。方法采用64只5周龄ApoE~(-/-)复制AS模型。随机分为6组:模型组(A组),阿托伐他汀钙组(B组),低剂量活血药对组(C组),低剂量破血药对组(D组),高剂量活血药对组(E组),高剂量破血药对组(F组)。连续灌胃给药8周后,处理动物。选用RT-PCR检测主动脉组织PLEK、PLK3表达并分析其结果。结果活血药对(当归、川芎)、破血药对(三棱、莪术)均可明显下调PLEK、PLK3基因mRNA表达量(P

Objective To observe the effect of different dosages of blood - activating couplet medicines (angelica sinensis and ligusticum wallichii) and blood - breaking couplet medicines (rhizoma sparganii and curcuma zedoary) on gene expression of Platelet leukocyte C kinase substrate (PLEK) and Polo - like kinases 3 (PLK3) of atherosclerosis mice models. Methods 64 five - week - old ApoE gene deficient mice were made as atherosclerosis mice models,randomly divided into 6 groups : the model group (A group),atorvastatin group (B group),low dose of blood - activating group (C group),low dose of blood - b...