期刊论文

Effects of Zhitongjiangu decoction on microstructure of synovial membrane in knee osteoarthritis

中文

时珍国医国药

1008-0805

2018

29

8

1793-1795

10.3969/j.issn.1008-0805.2018.08.001

81603482:国家自然科学基金 2016JJ6115:湖南省自然科学基金 2015JJ6057:湖南省自然科学基金

本校为第一机构

目的 观察止痛健骨方对兔膝骨关节炎模型滑膜显微结构的影响。方法 将72只白兔随机分为正常对照组、模型对照组、止痛健骨低剂量组、止痛健骨高剂量组,每组各18只。除正常对照组外,采用木瓜蛋白酶制备兔膝骨关节炎模型。止痛健骨低剂量、高剂量组分别给与止痛健骨方低剂量、高剂量药物灌胃,正常对照组和模型对照组则给与生理盐水灌胃。在模型验证、实验灌胃第4周、第8周三个时间点,各组随机选择6只白兔,观察膝关节滑膜显微结构变化,进行评分。结果 在实验干预前、实验干预第4周、第8周,与正常对照组比较,模型对照组、止痛健骨低剂量组、止痛健骨高剂量组滑膜病理评分均上升,差异有统计学意义（P...

Objective To observe mierostrueture of synovial membrane of Zhitongjiangu decoction on knee osteoarthritis. Methods 72 rabbits were randomly divided into normal control group, model control group, Zhitongjiangu low dose group, Zhitongjiangu high dose group, each group with 18 rats in each, the preparation of rabbit model of KOA papain intraarticular injection of and model verification is successful, Zhitongjiangu low dose group, high dose group, to give the corresponding Zhitongjiangu recipe intragastric administration, and normal control group...