期刊论文

Study on Anti - lung Tumor Activity and Mechanisms of Polygonatum Polysaccharide

中文

时珍国医国药

1008-0805

2018

29

10

2368-2372

10.3969/j.issn.1008-0805.2018.10.021

湖南省教育厅优秀青年项目(16B194) 湖南省协同创新中心(培育)开放项目(HXZY-2015-015)

本校为第一机构

目的观察不同来源玉竹多糖对在体肿瘤和离体培养肺癌细胞的抑制作用,探讨其抑制作用的可能机制。方法以接种人肺癌细胞的裸鼠为荷瘤小鼠模型,观察不同来源的玉竹多糖对接种瘤体生长的抑制作用,以及促进肿瘤细胞凋亡的蛋白和基因的变化。以人肺癌细胞(A549)为模型,检测不同来源玉竹多糖的体外抗肿瘤活性。结果不同来源的玉竹多糖处理荷瘤小鼠后能有效抑制小鼠瘤体的生长以及体外肺癌细胞的增殖(P < 0.05);促进肺癌细胞以及瘤组织细胞的凋亡。结论玉竹多糖有显著的抗肿瘤作用,其作用机制可能与玉竹多糖抑制Wnt /β - catenin信号通路表达,从而降低细胞周期蛋白表达,阻止肺癌细胞增殖和诱导细胞凋亡...

Objective To study the inhibitory effect of Polysaccharide from Polygonatumon tumor growth (in vivo & in vitro),discuss the possible mechanism of tumor - inhibition. Methods The inhibitory effect of Polygonatum polysaccharide Pon tumor growth was observed in the mice models with implanted A549 cell. The change of protein and gene who induce cancer cellapoptosis was analyzed in tumor - bearing mouse. The activity of anti - human - lung - cancer - cell was determined by use of different source of Polygonatum polysaccharide. Results The growth of ...