期刊论文

Clinical research of ZhitongJianGu Decoction on 60 patients with Osteoarthritis

中文

时珍国医国药

1008-0805

2019

30

2

383-385

10.3969/j.issn.1008-0805.2019.02.040

国家自然科学基金(81603482) 湖南省自然科学基金(2016JJ6115) 中国博士后科学基金面上项目(2017M622586).

本校为第一机构

目的初步评价止痛健骨方治疗骨性关节炎的疗效和安全性。方法采用完全随机分组、阳性药物平行对照、双盲观察设计方案,纳入符合痰瘀阻络兼肝肾亏虚型骨性关节炎病例90例,按治疗组∶对照组2∶ 1比例分为两组。治疗组服止痛健骨丸,对照组服抗骨质增生丸,疗程4周。以病证主要症状分级计分变化、疼痛开始缓解及消失时间、不良反应及血、尿、便常规、心电图、肝肾功能为观察指标。结果治疗组骨性关节炎总显效率63.3%;对照组总显效率13.3%。治疗组与对照组证候总显效率分别为80.0%、43.3%。组间差异均有统计学意义(P < 0.01)。治疗组对关节疼痛开始缓解与消失时间优于对照(P < 0.01),研究过程中没有发...

Objective To evaluate the efficacy and safety of ZhitongJianGu Decoction on patients with osteoarthritis. Methods According to the design scheme of complete random group,parallel control of positive drugs and double-blind observation, randomly divided 90 patients who meet up with the case inclusion criteria into the treatment group(60 cases) and the control group (30 cases). The design scheme was designed with complete random group,parallel control of positive drugs and double-blind observation. The control group attended anti-hyperosteogeny pill,while the treatment group had ZhitongJianGu pil...