期刊论文

Study on chromatographic fingerprint information entropy and once sampling quantitation of single medical herbs from ancient classical prescriptions

中文

时珍国医国药

1008-0805

2020

31

04

975-979

10.3969/j.issn.1008-0805.2020.04.066

国家自然科学基金（81573691;81703824;81803729;81874507）； 湖南省教育厅创新平台开放基金项目（18K071）； 湖南中医药大学研究生科研创新课题（2018CX18）； 湖南省研究生科研创新项目（CX20190570）；

本校为第一机构

目的 从中药遗传多态性出发,结合Hardy-Weinberg群体平衡质量规律,探讨经典名方单味中药指纹图谱信息熵及最小一次投料量.方法 收集多个产地的多味中药材及其炮制品,运用信息论、遗传统计学原理及一次投料量数学模型,测定指纹图谱信息熵和一次投料量等参数.结果 各药材及炮制指纹图谱的峰数、峰面积、信息量的RSD变化均大于20％;信息熵的RSD均值为8.36％,小于10％,各药材的平衡质量(一次投料量)远大于《中国药典》规定.结论 中药作用物质基础存在“印迹模板”的信息熵稳定性规律,指纹图谱信息论及一次投料量可用于经典名方中药质量均一性、稳定性研究.

Objective From the genetic polymorphism of traditional Chinese medicine,combining with the law of Hardy-Weinberg population equilibrium quality,this paper discussed the information entropy of chromatographic fingerprint and the once sampling quantitation of Primary Standard of single medical herbs from ancient classical prescriptions.Methods Some kinds of Chinese materia medicas and their processed products from many places of origin were collected.Information entropy,genetic statistics principle and mathematical model of the once sampling quantitation were used to determine information entrop...