期刊论文

Study on Quality Stability and Transmission Law of Qianghuo Shengshitang

中文

时珍国医国药

1008-0805

2020

31

01

75-78

10.3969/j.issn.1008-0805.2020.01.024

81874344:国家自然科学基金 2018M640755:中国博士后科学基金 2019JJ40220:湖南省自然科学基金面上项目 kq1801034:湖南省长沙市科技局项目 2018CX52:创新基金

本校为第一机构

目的建立羌活胜湿汤单味药及复方汤剂的HPLC指纹图谱,并采用总量统计矩法进行分析,探讨单味-复方过程中的质量稳定性和传递性规律。方法采用加热回流提取、水提醇沉对羌活胜湿汤复方及各单味药材进行处理,取复方及单味供试品液分别进行HPLC指纹图谱测定,通过总量统计矩加合参数法分析单味-复方过程中化学成分及其含量的稳定性与传递性规律。结果按处方中七单味药材指纹图谱数据计算得羌活胜湿汤复方的总量零阶矩、一阶矩、二阶矩分别为5.10 × 10~4 mAu·s,11.95 min,89.81 min2, 而实际测得的总方指纹图谱的总量零阶矩、一阶矩、二阶矩分别为6.49 × 10~4 mAu·s,15.23 min,115.79 min2。结论单...

Objective To establish the HPLC fingerprint of single herb of Qianghuo Shengshitang and compound decoction,and to analyze the HPLC fingerprint by total statistical moment method for inquire the quality stability and transitivity law in the single- compound process. Methods Heat reflux extraction,water extraction and alcohol precipitation were used to process compound decoction and single herbs,HPLC fingerprints were used to determine the chemical constituents and their contents in the compound and single flavor solution. The stability and trans...