期刊论文

中文

时珍国医国药

1008-0805

2022

33

01

95-98

湖南省教育厅科学研究基金（18B237）； 湖南中医药大学药食同源功能性食品工程技术研究中心开放基金（2018YSTY02）；

本校为第一机构

目的探究芦根中各提取成分对大鼠急性酒精性肝损伤的保护作用。方法大鼠被随机分为空白组、模型组、阳性组、芦根多糖组、芦根果胶组、芦根提取物A组,每组9只,共54只。各组大鼠分别预防性给药14天后,除空白组外,其余各组给予体积分数50%的乙醇14ml/(kg BW)建立急性酒精性肝损伤模型。16h后测定大鼠血清中谷丙转氨酶(ALT) 、谷草转氨酶(AST) 、乳酸脱氢酶(LDH) 、甘油三酯(TG) 、极低密度脂蛋白(VLDL)含量,苏木精-伊红染色观察大鼠肝组织病理学变化。结果与模型组相比,芦根多糖组、芦根果胶组、芦根提取物A组大鼠血清中ALT、AST、LDH、TG、VLDL含量均明显下降,差异具有统计学意义(除芦根多糖组、...

Objective To investigate the protective effect of various extracts from Rhizoma Phragmitis on acute alcoholic hepatic injury in rats.Methods Rats were randomly divided into 6 groups(blank control,model control,drug control,RP polysaccharide group,RP pectin group,RP extract group A),with 9 rats in each group and a total of 54 rats.After prophylactic administration for 14 days,the rats in each group were given 14 mL/(kg BW)of ethanol with 50% volume fraction to establish the model of acute alcoholic liver injury,except for the blank group.After 16 h,the contents of alanine aminotransferase(ALT),...