Sirtuin 7 Promotes Alcohol-Associated Liver Injury via Modulating Myeloid Cell Chemokine (C-C Motif) Ligand 2 Secretion through the NF-κB Signaling Pathway

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成果类型：

期刊论文

作者：

Wang, Zhiqiang;Liang, Gaoshuang;Peng, Jinying;Gu, Yiying;Zhang, Xiangwen;...

通讯作者：

Li, Z

作者机构：

[Yu, Tingzi; Peng, Jinying; Gu, Yiying; Zhang, Xiangwen; Ding, Cong; Liang, Gaoshuang; Wang, Zhiqiang; Li, Zhuan] Hunan Normal Univ, Inst Interdisciplinary Studies, Engn Res Ctr Reprod & Translat Med Hunan Prov, Key Lab Model Anim & Stem Cell Biol Hunan Prov,Sch, Changsha, Peoples R China.

[Wang, Zhiqiang] Hunan Univ Chinese Med, Human Anat Teaching & Expt Ctr, Sch Med, Changsha, Peoples R China.

[Li, Zhuan] Hunan Normal Univ, Sch Pharmaceut Sci, 371 Tongzipo Rd, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Li, Z ] H

Hunan Normal Univ, Sch Pharmaceut Sci, 371 Tongzipo Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

期刊：

AMERICAN JOURNAL OF PATHOLOGY

ISSN：

0002-9440

年：

2025

卷：

195

期：

页码：

575-588

DOI：

10.1016/j.ajpath.2024.12.006

基金类别：

National Natural Science Foundation of China [82170607]; Hunan Provincial Natural Science Foundation of China [2022JJ10037]; Hunan Normal University School of Medicine [KF2022001, 2022XKQ0205, 2023JC101]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The pathogenesis of alcohol-associated liver disease (ALD) involves ethanol-induced enhancement of gut permeability, bacterial products released from intestine and intrahepatic inflammation, and liver damage. Hepatic macrophages play a crucial role in mediating inflammatory response by alcohol. Sirtuin 7 (SIRT7), a NAD + -dependent type III histone deacetylase, is being recognized as a therapeutic target in various human diseases. Emerging evidence shows that SIRT7 participates in immune regulation, but whether it is involved in ALD remains elu...

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Sirtuin 7 Promotes Alcohol-Associated Liver Injury via Modulating Myeloid Cell Chemokine (C-C Motif) Ligand 2 Secretion through the NF-κB Signaling Pathway

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