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A new labdane diterpenoid glycoside and other constituents from Inula nervosa (Asteraceae) and their chemotaxonomic importance

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成果类型:
期刊论文
作者:
Li, Wenchu;Yang, Yupei;Wu, Juanjiang;Jiang, Sai;Yang, Yong;...
通讯作者:
Wang, Wei;Jian, YQ
作者机构:
[Wang, Wei; Yang, Yupei; Li, Wenchu; Jiang, Sai; Jian, Yuqing; Guo, Tingsi; Wu, Juanjiang; Yang, Yong] Hunan Univ Chinese Med, Innovat Mat Med Res Inst, Sch Pharm, TCM & Ethnomedicine Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Wang, W; Jian, YQ ] H
Hunan Univ Chinese Med, Innovat Mat Med Res Inst, Sch Pharm, TCM & Ethnomedicine Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
Anti-inflammatory;Diterpenoid;Inula nervosa;Steroids
期刊:
Biochemical Systematics and Ecology
ISSN:
0305-1978
年:
2023
卷:
109
页码:
104662
基金类别:
Financial support of this research was provided by National Natural Science Foundation of China ( 82174078 ), Changjiang Scholars Program in Ministry Education, People's Republic of China ( T2019133 ), Hunan Administration of Tradition Chinese Medicine (Xiangcai 2021–105 ), Excellent Youth Project of Hunan Provincial Department of Education ( 22B0388 ), Project of Hunan Administration of Traditional Chinese Medicine ( B2023143 ), Opening Foundation of Hunan Key Laboratory of Natural Medicine Resources and Functions ( 2022ZYYGN03 ), and Opening Foundation of Traditional Chinese Medicine Processing Technology Inheritance Base of State Administration of Traditional Chinese Medicine ( 2022ZYPZ08 ).
机构署名:
本校为第一且通讯机构
院系归属:
药学院
摘要:
The chemical investigation of the Inula nervosa Wall. (Asteraceae) led to the isolation of a new labdane diterpenoid glycoside, maoxiucaioside A (1), and ten known compounds including seven steroids (2–8), one triterpenoid (9), and two flavonoids (10 and 11). Their structures were elucidated based on NMR, HRESIMS and ECD data analysis as well as literature data. Moreover, the anti-inflammatory activities of all isolates were evaluated by measuring their inhibitory effects on inflammatory cytokines (IL-1β, IL-6, and TNF-α) production in LPS-s...

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