Targeting neuroinflammation: The therapeutic potential of ω-3 PUFAs in substance abuse

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Peng, Sha;Peng, Zhuang;Qin, Meng;Huang, Lu;Zhao, Bin;...

通讯作者：

Shi, Zhe;Liao, DF

作者机构：

[Peng, Zhuang; Liao, Duan-Fang; Peng, Sha; Liao, DF; Tuo, Qin-Hui; Shi, Zhe; Shi, Z] Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha, Hunan, Peoples R China.

[Qin, Meng] Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing, Peoples R China.

[Huang, Lu] Jinan Univ, Guangdong Hongkong Macau Inst CNS Regenerat, Minist Educ CNS Regenerat Collaborat Joint Lab, Guangzhou, Peoples R China.

[Wei, Lai; Zhao, Bin] Xinxiang Med Univ, Sch Forens Med, Xinxiang Key Lab Forens Toxicol, Xinxiang, Henan, Peoples R China.

[Ning, Jie] Shenzhen Longhua Dist Cent Hosp, Dept Metab Endocrinol, Shenzhen, Peoples R China.

通讯机构：

[Liao, DF ; Shi, Z] H

Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

omega 3 fatty acid;omega 3 fatty acid;causal attribution;clinical effectiveness;drug dependence;drug efficacy;human;immunoregulation;innate immunity;nerve cell plasticity;nervous system inflammation;nonhuman;priority journal;Review;species richness;substance abuse;tobacco dependence;treatment outcome;treatment planning;addiction;drug dependence;Behavior, Addictive;Fatty Acids, Omega-3;Humans;Substance-Related Disorders

期刊：

Nutrition

ISSN：

0899-9007

年：

2021

卷：

页码：

111058

DOI：

10.1016/j.nut.2020.111058

基金类别：

This work was supported by the Natural Science Foundation of Guangdong (2016A030313026), the Scientific Research Fund of Hunan Provincial Education (19B422), the National Natural Science Foundation of China (no. 81701862 and 52003021), and the Program of Key Research in University of Henan Province (no.18A310025 and 18A310024). All authors wrote the draft and approved the final version. The authors have no conflicts interest to declare.

机构署名：

本校为第一且通讯机构

摘要：

Substance abuse is a chronic relapsing disorder that results in serious health and socioeconomic issues worldwide. Addictive drugs induce long-lasting morphologic and functional changes in brain circuits and account for the formation of compulsive drug-seeking and drug-taking behaviors. Yet, there remains a lack of reliable therapy. In recent years, accumulating evidence indicated that neuroinflammation was implicated in the development of drug addiction. Findings from both our and other laboratories suggest that ω-3 polyunsaturated fatty acid...

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Targeting neuroinflammation: The therapeutic potential of ω-3 PUFAs in substance abuse

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