PCSK9 promotes the secretion of pro-inflammatory cytokines by macrophages to aggravate H/R-induced cardiomyocyte injury via activating NF-κB signalling

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成果类型：

期刊论文

作者：

Yang, Cheng-Long;Zeng, Yi-Di;Hu, Zhi-Xi*;Liang, Hao

通讯作者：

Hu, Zhi-Xi;Liang, H

作者机构：

[Yang, Cheng-Long] Hunan Univ Chinese Med, Cardiovasc Dept, Hosp 1, Changsha, Hunan, Peoples R China.

[Yang, Cheng-Long] Hunan Univ Chinese Med, TCM Sch 1, Changsha, Hunan, Peoples R China.

[Hu, Zhi-Xi; Liang, H; Liang, Hao; Hu, ZX; Zeng, Yi-Di] Hunan Univ Chinese Med, Inst TCM Diagnost, Changsha 410208, Hunan, Peoples R China.

[Hu, Zhi-Xi; Liang, H; Liang, Hao; Hu, ZX; Zeng, Yi-Di] Hunan Univ Chinese Med, Hunan Prov Key Lab TCM Diagnost, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Liang, H ; Hu, ZX] H

Hunan Univ Chinese Med, Inst TCM Diagnost, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Hunan Prov Key Lab TCM Diagnost, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

PCSK9;Cardiomyocytes;Macrophages;Pro-inflammatory cytokines;NF-kappa B signalling

期刊：

GENERAL PHYSIOLOGY AND BIOPHYSICS

ISSN：

0231-5882

年：

2020

卷：

期：

页码：

123-134

DOI：

10.4149/gpb_2019057

基金类别：

Acknowledgements. This work was supported by the National Natural Science Foundation of China (81503627, 81774207 and 81774208), and Scientific Research Project of Hunan Provincial Department of Education (18K070). The funding body did not have any role in the design of the study, the collection, analysis and interpretation of the data or the writing of the manuscript.

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

第一中医临床学院

摘要：

The upregulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) was reported to be involved in regulating the levels of inflammatory markers and apoptosis in macrophages. This study aims to investigate the function and regulation of PCSK9 in myocardial ischaemia. The results of our study showed dramatically increased expression of PCSK9 induced by hypoxia/reoxygenation (H/R) stress rather than by apoptosis in primary murine cardiomyocytes and HL-1 cells. Moreover, PCSK9 promoted H/R-induced pro-inflammatory cytokine release from macrophages, while silencing of PCSK9 inhibited the exp...

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PCSK9 promotes the secretion of pro-inflammatory cytokines by macrophages to aggravate H/R-induced cardiomyocyte injury via activating NF-κB signalling

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