期刊论文、会议论文

Effects of Xianti Jiangzhi ? on regulation of brain-gut peptide and obesity prevention in ovariectomized rats

中文

中华中医药杂志

1673-1727

2016

31

5

1979-1983

第七届全国中医药博士生学术论坛

第七届全国中医药博士生学术论坛论文集

2016-04-22

合肥

中华中医药学会<&wdkj&>北京岐黄中医药文化发展基金会

广东省科技计划项目（No.2013B021800085） 清远市科技计划项目（No.2013A010）~~

本校为其他机构

目的:研究纤体降脂Ⅰ号对去卵巢大鼠脑肠肽的影响,探讨其纤体降脂的作用机制. 方法:72只SD大鼠按体质量随机分为假手术组12只,造模组60只,造模组采用双侧去卵巢法造模,假手术组只切除卵巢周围相应质量的脂肪.造模成功后,造模组大鼠按体质量随机分为模型组,纤体降脂Ⅰ号高(13.2g/kg)、中(6.6g/kg)、低剂量组(3.3g/kg)和戊酸雌二醇(0.021mg/kg)组,每组12只.术后第5天开始药物干预,模型组和假手术组给予相应体积的纯净水,持续13周.给药结束后,ELISA法检测血清降钙素基因相关肽(CGRP)、胃动素(MTL)、胃泌素(GAS)、血管活性肠肽(VIP)、胆囊收缩素(CCK)、胃促生长素(ghrelin)的含量,免疫组化检测下丘...

Objective: To explore the effect of Xianti Jiangzhi Ⅰ on the brain-gut peptide in ovariectomized rats and investigate its mechanism in losing weight and reducing fat. Methods: Seventy-two SD rats weight about 200g were randomly divided into sham group (n=12) and model group (n=60), the rats in model group were ovariectomized on both sides and in sham group were excised equal weight fat. After the modeling, the rats were randomly divided into model group, Xianti Jiangzhi Ⅰ high, middle, low-dose (13.2g/kg, 6.6g/kg, and 3.3g/kg) group and estra...