Efficacy of decoction from Jieduan Niwan formula on rat model of acute-on-chronic liver failure induced by porcine serum

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成果类型：

期刊论文

作者：

Li Jinxia;Zhang Qiuyun*;Gao Lianyin;Du Yuqiong;Chen Yu

通讯作者：

Zhang Qiuyun

作者机构：

[Li Jinxia] Hunan Univ Chinese Med, Inst Tradit Chinese Med Diag, Changsha 410208, Peoples R China.

[Li Jinxia] Hunan Key Lab Tradit Chinese Med Diag, Changsha 410208, Peoples R China.

[Zhang Qiuyun; Du Yuqiong; Gao Lianyin] Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China.

[Zhang Qiuyun; Du Yuqiong; Gao Lianyin] Beijing Key Lab Tradit Chinese Med Collateral Dis, Beijing 100069, Peoples R China.

[Chen Yu] Capital Med Univ, Beijing You An Hosp, Dept Artificial Liver, Beijing 100069, Peoples R China.

通讯机构：

[Zhang Qiuyun] C

Capital Med Univ Sch, Sch Tradit Chinese Med, Beijing 100069, Peoples R China.

语种：

英文

关键词：

Acute-on-chronic liver failure;Apoptosi;JNK mitogen-activated protein kinase;Jieduan Niwan formula

期刊：

中医杂志(英文版)

ISSN：

0255-2922

年：

2020

卷：

期：

页码：

602-612

DOI：

10.19852/j.cnki.jtcm.2020.04.009

基金类别：

(No.81573767):Supported by National Natural Science Foundation of China: Mechanisms of Heprescription of Truncation and Inverse Draft on Preventing and Treating Acute-on-Chronic Liver Failure Based on E2F1 Induced Hepatocytic Proliferation and Apoptosis

机构署名：

本校为第一机构

院系归属：

中医学院

摘要：

OBJECTIVE: To dynamically observe the efficacy of Jieduan Niwan formula (JDNW) on a rat model of acute-on-chronic liver failure (ACLF). METHODS: Seventy Wistar rats were divided into control group (6 rats), model group (22 rats), JDNW group (21 rats), and SP600125 group (21 rats). 13 weeks' porcine serum injection followed with D-galactosamine and lipopolysaccharide joint acute attack was used to establish ACLF model. Rats in JDNW group were orally given JDNW formula for 3 days before acute attack; rats in SP600125 group were injected with SP600125 30 min ahead of acute attack. Rats were sacri...

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Efficacy of decoction from Jieduan Niwan formula on rat model of acute-on-chronic liver failure induced by porcine serum

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