期刊论文

Chen Naihong;Li Yueting

英文

中医杂志(英文版)

0255-2922

2020

40

4

584-592

10.19852/j.cnki.jtcm.2020.04.007

:Supported by the National Natural Science Foundation of China (the Mechanism of Treating Cholelithiasis Based on the Theory of Biliary Diseases Treated by Differentiating Syndromes of the Liver,No,81473570) (No,2018ZX09711001-002-007,2018-ZX09711001-003-005,2018ZX09711001-009-013):the Drug Innovation Major Project (BZ0150):Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study

本校为通讯机构

OBJECTIVE: To investigate efficacy of Lidan Tang (LDT) on gallstone induced by high fat diet in mice, and to study its underlying mechanism. METHODS: Mice were fed with high fat diet every day and treated with LDT (9.01 times of human clinic dosage). Mice were randomly divided into 6 groups as control group, gallstone model group (high-fat diet), positive control ursodeoxycholic acid (UDCA) group (80 mg.kg(-1).d(-1) i.g.), LDT low dose group (6 kg/d, i.g.), LDT middle dose group (12 kg/d, i.g.), and LDT high dose group (24 kg/d, i. g.). The whole experiment was lasted for 4 weeks. The levels o...