期刊论文

Comprehensive Traditional Chinese Medicine Therapeutic Scheme in Maintenance Treatment for Advanced Non-small Cell Lung Cancer: a Multicenter, Large-sample and Prospective Cohort Study

中文

中医杂志

1001-1668

2020

61

8

690-694

10.13288/j.11-2166/r.2020.08.011

中医药行业科研专项(201307006) 中国中医科学院中央级公益性科研院所基本科研业务费(ZZ13-024-6)。

本校为第一机构

目的 探讨中医综合治疗方案维持治疗晚期非小细胞肺癌的临床疗效及安全性.方法 采用多中心、大样本、前瞻性队列研究方法,纳入化疗2～4个周期后疗效评价疾病稳定以上进入维持阶段患者,根据患者意愿分为治疗组126例、对照组123例.对照组给予化疗药物进行维持治疗,治疗组进行中医综合治疗方案(汤药、中药注射液、中成药)维持治疗.21 ～28天为1个疗程,两组干预至少2个疗程.比较两组疾病无进展生存时间(PFS)、中位生存期(OS)、生活质量,同时进行药物安全性评价.结果 229例患者出现PFS终点事件(91.97％),其中治疗组114例,中位PFS为152天;对照组115例,中位PFS为161天,两组PFS比较差异无统计学意义(P＞...

Objective To explore clinical efficacy and safety of comprehensive traditional Chinese medicine (TCM) therapeutic scheme in maintenance treatment for advanced non-small cell lung cancer (NSCLC). Methods A multicenter, large-sample, prospective cohort study was conducted. After 2-4 cycles of chemotherapy, patients entering the maintenance stage with efficacy evaluation of stable disease (SD) and above were enrolled into two groups according to their intention, including 126 cases in treatment group and 123 cases in control group. The maintenance treatment in the control group was given chemothe...