期刊论文

英文

中医杂志

1001-1668

2021

41

3

447-454

10.19852/j.cnki.jtcm.2021.03.013

Supported by Natural Science Foundation of Hunan Province of China （the Mechanism of Zhuifengtougu Capaule on the Cold and Heat Syndrome Animal Model of Reheumatod Arthritis in Rats on the "Syndrome-Molecular" No.2017JJ2190, Research the Effect Mechanism of Zhuifengtougu Capsule on the Knee Osteoarthritis Base on TLR4-My D88Pathway Mediated by Intestinal Microbiome, 2019JJ50462）；

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OBJECTIVE: To investigate the efficacy of Zhuifeng tougu capsules, ZFTG) in the treatment of rheumatoid arthritis (RA) in rats and study its mechanism, focusing on the toll-like receptor 2/ 4-nuclear factor kappa-B (TLR2/4-NF-kappa B) signaling pathway. METHODS: Type. collagen and an artificial climate box were used to construct the rat model of collagen-induced arthritis with wind-cold-dampness arthralgia syndrome. The rats were divided randomly into a control group, wind-cold-dampness syndrome model group, and high-, medium-, and low-dose ZFTG groups. The methotrexate (MTX) control group was...

OBJECTIVE: To investigate the efficacy of Zhuifeng tougu capsules(追风透骨胶囊, ZFTG) in the treatment of rheumatoid arthritis(RA) in rats and study its mechanism, focusing on the toll-like receptor 2/4-nuclear factor kappa-B(TLR2/4-NF-κB) signaling pathway.METHODS: TypeⅡ collagen and an artificial climate box were used to construct the rat model of collagen-induced arthritis with wind-cold-dampness arthralgia syndrome. The rats were divided randomly into a control group, wind-cold-dampness syndrome model group, and high-, medium-,and low-dos...