期刊论文

Metabolomics of the Saliva in Psoriasis Vulgaris Patients with Blood Heat Pattern,Blood Stasis Pattern and Blood Dryness Pattern Based on Widely Targeted Metabonomics Techniques

中文

中医杂志

1001-1668

2021

62

09

789-795

10.13288/j.11-2166/r.2021.09.011

国家自然科学基金（81704091）； 中国博士后科学基金（2019M653348）； 重庆市自然科学基金（cstc2019jcyj-msxmX0757）；

本校为第一机构

目的研究寻常型银屑病不同证候唾液差异代谢物,探讨其证候物质基础。方法招募寻常型银屑病血热证（21例）、血瘀证（13例）、血燥证（11例）患者为疾病组,以及同时期健康志愿者30例设为正常对照组。采用UPLC-MS/MS检测平台、自建数据库以及多元统计分析相结合的方法研究寻常型银屑病各证型组与正常对照组受试者唾液样本代谢组差异,经主成分分析筛选证候相关的生物标志物,利用KEGG数据库对筛选的差异代谢物进行注释和通路富集。结果 75份唾液样本共检测到368个代谢物,与正常对照组比较,特征性差异代谢物血热证组有3-（3-羟基苯基）丙酸等9个,血瘀证组有环己基氨基磺酸等7个,血燥证组有月桂酸等4个...

Objective To explore the material basis of different patterns of psoriasis vulgaris (PV)by analyzing the salivary metabolic profiles.Methods Forty-five PV patients with blood heat pattern (21 cases),blood stasis pattern (13 cases),or blood dryness pattern (11 cases)were recruited as the disease group,while 30 healthy volunteers during the same period were recruited as the normal control group.The UPLC-MS/MS detection platform,self-built database,and multivariate statistical analysis were used to compare the differences in the metabolites of saliva samples between different PV pattern groups an...