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Effects of Qingguang'an(青光安)containing serum on the expression levels of autophagy-related genes in human Tenon's fibroblasts induced by transforming growth factor beta 1

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成果类型:
期刊论文
作者:
Yu Juan;Xia Fei;Li Xiang;Peng Qinghua
作者机构:
[Yu Juan; Xia Fei; Li Xiang; Peng Qinghua] Hunan Univ TCM, Affiliated Hosp 1, Ophthalmol Dept, Changsha 410007, Peoples R China.
[Yu Juan; Peng Qinghua] Hunan Univ Tradit Chinese Med, Eye Res Ctr, Changsha 410208, Peoples R China.
[Peng Qinghua] Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha 410208, Peoples R China.
语种:
英文
关键词:
Qingguang'an medicated serum;Transforming growth factor beta 1;beclin-1;autophagy-related protein 5;microtubule-associated proteins;Human Tenon's fibroblasts
期刊:
中医杂志(英文版)
ISSN:
0255-2922
年:
2021
卷:
41
期:
2
页码:
236-245
基金类别:
Supported by the National Natural Science Foundation of China (Inducing effect of Qingguang’an on Autophagy of Tenon’s Capsule Fibroblasts after Glaucoma Filtration Surgery, No. 81603665); the Postdoctoral Science Foundation of China (Experimental Study on Autophagy of Tenon’s Fibroblasts Induced by Qingguang’an after Glaucoma Filtration Surgery, No. 2017M612565);
机构署名:
本校为第一机构
院系归属:
第一中医临床学院
摘要:
OBJECTIVE: To explore the effects of Qingguang'an (...) containing serum on the expression levels of autophagy related genes in the transforming growth factor beta 1 (TGF-beta 1)-activated human Tenon's fibroblasts (HTFs). METHODS: (a) Primary HTFs were stimulated by TGF-beta 1 and underwent immunohistochemistry, which established a cell model after Glaucoma filtration surgery (GFS). (b) The cell models were divided into 4 group: normal group (normal cells), model group (+TGF-beta 1), treatment group (+TGF-beta 1+ medicated serum), and positive control group (TGF-beta 1+ rapamycin). Then, Qing...
摘要(中文):
OBJECTIVE: To explore the effects of Qingguang’an(青光安) containing serum on the expression levels of autophagy related genes in the transforming growth factor beta 1(TGF-β1)-activated human Tenon’s fibroblasts(HTFs).METHODS:(a) Primary HTFs were stimulated by TGF-β1 and underwent immunohistochemistry,which established a cell model after Glaucoma filtration surgery(GFS).(b) The cell models were divided into 4 group: normal group(normal cells),modelgroup(+TGF-β1),treatmentgroup(+TGF-β1+medicated serum), and positive cont...

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