Efficacy of Baishao Luoshi decoction ((sic)) on synaptic plasticity in rats with post stroke spasticity

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成果类型：

期刊论文

作者：

Xie, Le;Mao, Guo;Xie, Yao;Cao, Sijia;Zhou, Shen;...

作者机构：

[Kang, Fuliang; Wu, Dahua; Xie, Yao; Xie, Le; Ge, Jinwen; Yao, Ting; Fan, Jianhu; Jiang, Junlin; Mao, Guo; Zhou, Shen] Hunan Acad Chinese Med, Neurol Dept, Changsha 410006, Peoples R China.

[Cao, Sijia] Hunan Univ Chinese Med, Sch Humanities & Management, Changsha 410208, Peoples R China.

[Liu, Dong] Guizhou Univ Tradit Chinese Med, Coll Pharm, Guiyang 550002, Peoples R China.

[Ge, Jinwen] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Peoples R China.

[Wu, Dahua] Hunan Acad Chinese Med, Neurol Dept, Affiliated Hosp, Changsha 410006, Peoples R China.

语种：

英文

关键词：

Baishaoluoshi decoction;infarction, middle cerebral artery;neuroprotection;post stroke spasticity;synaptic plasticity

期刊：

中医杂志

ISSN：

1001-1668

年：

2023

卷：

期：

页码：

295-302

DOI：

10.19852/j.cnki.jtcm.20221108.002

基金类别：

China Postdoctoral Science Foundation [2020M682571]; Natural Science Foundation of Hunan Province China [2019JJ50343]; Scientific Research Project of Education Department of Hunan Province [19C1423]

机构署名：

本校为第一机构

院系归属：

中西医结合学院

摘要：

OBJECTIVE: To evaluate the efficacy of Baishao Luoshi decoction ((sic), BD) on synaptic plasticity in rats with post stroke spasticity (PSS), and to study the mechanism behind the action. METHODS: The PSS model of rat was established by middle cerebral artery occlusion (MCAO). The neurological deficit symptoms were evaluated by modified neurological deficit score (mNSS). Muscle tension were evaluated by Modified Ashworth score (MAS). Transmission electron microscopy (TEM) was used to observe the synaptic ultrastructure. The expression of synaptic plasticity-related protein brain derived neurot...

摘要(中文)：

OBJECTIVE:To evaluate the efficacy of Baishao Luoshi decoction(白芍络石方,BD)on synaptic plasticity in rats with post stroke spasticity(PSS),and to study the mechanism behind the action.METHODS:The PSS model of rat was established by middle cerebral artery occlusion(MCAO).The neurological deficit symptoms were evaluated by modified neurological deficit score(mNSS).Muscle tension were evaluated by Modified Ashworth score(MAS).Transmission electron microscopy(TEM)was used to observe the synaptic ultrastructure.The expression of synaptic plasticit...

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Efficacy of Baishao Luoshi decoction ((sic)) on synaptic plasticity in rats with post stroke spasticity

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