Metabolomic mechanism and pharmacodynamic material basis of Buxue Yimu pills in the treatment of anaemia in women of reproductive age

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成果类型：

期刊论文

作者：

Guo, Ying-ying;Wang, Yan-fang;Deng, Yan;Zhang, Su-ying;Liu, Dong;...

作者机构：

[Deng, Yan; Ma, Rui-lin; Guo, Ying-ying; Wang, Yan-fang] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China.

[Zhang, Su-ying] Hunan Univ Chinese Med, Dept Obstet & Gynecol, Affiliated Hosp 2, Changsha, Peoples R China.

[Luo, Bin; Liu, Dong] Sichuan Univ, West China Hosp 2, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Peoples R China.

[Luo, Bin; Liu, Dong] Sichuan Univ, Minist Educ, Chengdu, Peoples R China.

[Wang, Xue; Deng, Miao] Hangzhou Matern & Child Healthcare Hosp, Hangzhou Womens Hosp, Dept Obstet & Gynecol, Hangzhou, Peoples R China.

语种：

英文

关键词：

metabolomic;pharmacodynamic;anaemia;Buxue Yimu pills;iron stasis

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2023

卷：

DOI：

10.3389/fphar.2022.962850

基金类别：

National Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology; Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

机构署名：

本校为其他机构

院系归属：

第二中医临床医学院

摘要：

Objective: To explore the pharmacological basis and mechanism of Buxue Yimu pills (BYP) in the treatment of anaemia in women from the perspective of metabolomics and network analysis.Materials and Methods: Forty-six women of reproductive age with haemoglobin 70-110 g/L were recruited. Blood samples were collected before and after 4 weeks of oral BYP treatment to assess the changes in haemoglobin, coagulation function, and iron metabolism indices. An integrated analysis of metabolomics (liquid chromatography mass spectrometry) and network analysis was performed to identify the potential pharmac...

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Metabolomic mechanism and pharmacodynamic material basis of Buxue Yimu pills in the treatment of anaemia in women of reproductive age

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