期刊论文

中文

中国中医药信息杂志

1005-5304

2010

17

5

29-30

10.3969/j.issn.1005-5304.2010.05.012

国家自然科学基金（30772874） 湖南省自然科学基金（06JJ50054）

本校为第一机构

目的 探讨七味白术散对人类轮状病毒(HRV)感染乳鼠小肠黏膜上皮细胞的保护作用.方法 5日龄NIH乳鼠经口感染HRV建立乳鼠腹泻模型,随机分为4组:正常组、模型组、七味白术散组、病毒唑组,各组乳鼠分别经口滴入相对应的治疗药物,3次/d(正常化与模型组给生理盐水).分别于治疗后5 d处死乳鼠,取乳鼠小肠粪便检测HRV,HE染色观察小肠黏膜病理变化.结果 七味白术散治疗5 d乳鼠肠粪便中HRV清除率明显优于模型组(P＜0.05);七味白术散组乳鼠小肠黏膜上皮细胞病变明显减轻,与模型组、病毒唑组比较差异均有统计学意义(P＜0.05).结论 七味白术散能清除感染乳鼠肠道中的HRV,明显改善HRV感染乳鼠小肠黏膜上皮细胞病...

Objective To investigate the protective effect of Qiweibaizhu Powder against HRV infection of intestinal mucosal epithelial cells of suckling mice. Methods The 5-day-old NIH mice were made HRV diarrhea model by oral infection, and randomly divided into six groups： normal group （NG）, model group （MG）, Qiweibaizhu Powder group （BG）, ribavirin group （ZG）, suckling mice in each group were instilled corresponding drugs 3 times/d （NG and MG with normal saline） through the mouth. 5 d after treatment, suckling mice were killed, small intesti...