USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Song, Mingyu;Yi, Fang;Zeng, Feiyue;Zheng, Lan;Huang, Lei;...

通讯作者：

Gu, WP

作者机构：

[Gu, Wenping; Zheng, Lan; Huang, Qianyi; Sun, Xinyu; Gu, WP; Song, Mingyu] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China.

[Gu, Wenping; Yi, Fang; Gu, WP; Song, Mingyu] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.

[Gu, Wenping; Gu, WP; Song, Mingyu] Cent South Univ, Clin Res Ctr Cerebrovasc Dis Hunan Prov, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

[Wang, Hong; Yi, Fang] Cent South Univ, Xiangya Hosp, Dept Geriatr Neurol, Changsha 410008, Hunan, Peoples R China.

[Zeng, Feiyue] Cent South Univ, Xiangya Hosp, Dept Radiol, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Gu, WP ] C

Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.

Cent South Univ, Clin Res Ctr Cerebrovasc Dis Hunan Prov, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Ischemic stroke;Mitophagy;USP18;FTO;SIRT6

期刊：

Molecular Neurobiology

ISSN：

0893-7648

年：

2024

页码：

1-17

DOI：

10.1007/s12035-024-04001-1

基金类别：

This work was supported by the National Nature Science Foundation of China (No. 81901223).

机构署名：

本校为其他机构

摘要：

Ischemic stroke (IS) is a dangerous cerebrovascular disorder with a significant incidence and death rate. Ubiquitin-specific peptidase 18 (USP18) has been proven to mitigate ischemic brain damage; however, its potential regulatory mechanisms remain unclear. In vivo and in vitro models of IS were established by middle cerebral artery occlusion (MCAO) and oxygen-glucose deprivation/reoxygenation (OGD/R). Neurocyte injury was detected by MTT, LDH, ROS level, mitochondrial membrane potential (Delta psi m), and flow cytometry. Molecular expression was evaluated by qPCR, Western blotting, and immuno...

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USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6

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