Silencing of PPMD1 inhibits proliferation of human colon cancer cells via induction of apoptosis and cell cycle arrest

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yin, Zhihui;Yi, Jian;Nie, Tian;Yang, Zongliang;Ding, Ning;...

通讯作者：

Peng, Tianshu

作者机构：

[Yin, Zhihui] Univ South China, Affiliated Hosp 1, Dept Anorectal Dis, Hengyang 421001, Hunan, Peoples R China.

[Yi, Jian] Hunan Univ Tradit Chinese Med, Hosp 1, Key Lab Internal Med, Changsha 410007, Hunan, Peoples R China.

[Nie, Tian] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Blood & Oncol, Changsha 410007, Hunan, Peoples R China.

[Du, Shou Xian; Yang, Zongliang; Ding, Ning; Peng, Tianshu; Liu, Shan Shan] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Anorectal Dis, 233 Cai E North Rd, Changsha 410005, Hunan, Peoples R China.

通讯机构：

[Peng, Tianshu] H

Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Anorectal Dis, 233 Cai E North Rd, Changsha 410005, Hunan, Peoples R China.

语种：

英文

关键词：

PPMD1;colon cancer;apoptosis;cell cycle arrest invasion

期刊：

Journal of BUON

ISSN：

1107-0625

年：

2019

卷：

期：

页码：

1464-1469

基金类别：

Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [2017 JJ3230]; Hunan Provincial Department of Education Science Research Project [17C1233]

机构署名：

本校为通讯机构

院系归属：

第一中医临床学院

第二中医临床医学院

摘要：

Purpose: Accumulating reports have shown the oncogenic properties of PPMD1 (protein phosphatase, Mg2+/Mn2+ dependent 1D) in different cancer types. This study was undertaken to explore the role and therapeutic potential of PPM1D in colon cancer. Methods: HT-29 colon cancer cell line was used in this study. Expression analysis of PPMD1 was performed by qRT-PCR. Cell viability was determined by CCK-8 assay. DAPI, acridin orange/ethidium bromide (AO/EB) and propidium iodide (PI) staining assays were used for apoptosis detection. Cell cycle analysis was performed by flow cytometry. Protein express...

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Silencing of PPMD1 inhibits proliferation of human colon cancer cells via induction of apoptosis and cell cycle arrest

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