Siwu Paste protects bone marrow hematopoietic function in rats with blood deficiency syndrome by regulating TLR4/NF-κB/NLRP3 signaling pathway

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成果类型：

期刊论文

作者：

Du, Qing;He, Dan;Zeng, Hong-Liang;Liu, Jian;Yang, Hui;...

通讯作者：

Cai, Ping;Huang, Jian-hua;Zhang, SH

作者机构：

[Huang, Jian-hua; Zhang, Shui-han; Wan, Dan; Cai, Ping; Du, Qing; He, Dan; Zeng, Hong-Liang; Zhang, SH; Xu, Lin-Ben] Hunan Univ Chinese Med, Hunan Acad Chinese Med, Changsha 410013, Hunan, Peoples R China.

[Yang, Hui; Liu, Jian] Hunan Univ Chinese Med, Cent Lab, Hosp 1, Changsha 410007, Hunan, Peoples R China.

[Liang, Hao] Hunan Univ Chinese Med, Inst TCM Diagnost, Changsha 410208, Hunan, Peoples R China.

[Tang, Chun-Yu] Hunan Times Sunshine Pharmaceut Co Ltd, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Huang, JH; Zhang, SH ; Cai, P] H

Hunan Univ Chinese Med, Hunan Acad Chinese Med, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

acteoside;adenosine triphosphatase (calcium magnesium);adenosine triphosphatase (potassium sodium);albiflorin;Chinese medicinal formula;cryopyrin;cytokine;gallic acid;hematologic agent;hemoglobin;immunoglobulin enhancer binding protein;interleukin 1beta;interleukin 3;interleukin 6;paeoniflorin;siwu paste;toll like receptor 4;unclassified drug;cryopyrin;herbaceous agent;immunoglobulin enhancer binding protein;Nlrp3 protein, rat;Tlr4 protein, rat;toll like receptor 4;anemia;Angelica sinensis;animal cell;animal experiment;animal model;animal tissue;Article;blood;blood deficiency syndrome;blood deficiency syndrome;BMSC cell line;bone marrow;cell viability;controlled study;dose response;drug megadose;energy metabolism;enzyme activity;enzyme linked immunosorbent assay;erythrocyte;erythrocyte membrane;femur;hematocrit;hematologic disease;hematopoiesis;high performance liquid chromatography;leukocyte;Ligusticum sinense;low drug dose;male;nonhuman;Paeonia lactiflora;protein expression;rat;Rehmannia glutinosa;signal transduction;spleen;thrombocyte;thymus atrophy;Western blotting;animal;bone marrow cell;drug effect;hematologic disease;hematopoiesis;isolation and purification;metabolism;ointment;physiology;randomization;Sprague Dawley rat;Animals;Bone Marrow Cells;Drugs, Chinese Herbal;Hematologic Diseases;Hematopoiesis;Male;NF-kappa B;NLR Family, Pyrin Domain-Containing 3 Protein;Ointments;Random Allocation;Rats;Rats, Sprague-Dawley;Signal Transduction;Toll-Like Receptor 4

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2020

卷：

262

页码：

113160

DOI：

10.1016/j.jep.2020.113160

基金类别：

This work was supported by Natural Science Foundation of China (No. 81673585 ), China Postdoctoral Science Foundation ( 2019M652776 ); Key Research and Development Project of Hunan Province Science and Technology ( 2019XF5064 , 2019XF5062 ); Key Research and Development Project of Changsha Science and Technology ( kq1901067 ); Training Program for Excellent Young Innovators of Changsha ( kq1802017 ); Science Foundation of Hunan Province ( 2019JJ50345 ); Provincial Key Project of Hunan Academy of Traditional Chinese Medicine (No. 201803 , No. 201805 ); Program of Survey of Chinese Medicines of China ( [2017]66 ), Program of Survey and Monitoring of Chinese Medicines for National Drugs ( [2013] 135 ); Construction Project of Quality Monitoring System of Raw Materials of Chinese Medicine (No. [2014]76 ); Construction Project of Seedling Base of Rare Chinese Medicinal and Processing Technology of Chinese Medicinal Materials ( [2015]78 ). Thanks the support of Hunan Province traditional Chinese medicine preparation and quality traceability engineering and technology center.

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

第一中医临床学院

摘要：

Ethnopharmacological relevance: Siwu Paste (SWP) was recorded in the first national Pharmacopoeia of China, “Tai Ping Hui Min He Ji Ju Fang”, it showed excellent effects in regulating all syndromes relevant to blood. Aim of the study: This study aimed to investigate the protective effects of Siwu Paste (SWP) on bone marrow hematopoietic by using rats’ model with blood deficiency syndrome induced by chemotherapy. Materials and methods: Animal model with blood deficiency syndrome was successfully established by evaluating their peripheral bloo...

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Siwu Paste protects bone marrow hematopoietic function in rats with blood deficiency syndrome by regulating TLR4/NF-κB/NLRP3 signaling pathway

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