期刊论文

中文

中国医药工业杂志

1001-8255

2016

47

9

1194-1198

10.16522/j.cnki.cjph.2016.09.013

湖南省科技计划重大专项项目（2010FJ1010-3） 国家中医药管理局“药用植物学”重点学科课题（国中医药发[2009]30号） 湖南省高校科技创新团队资助项目（湘教通[2010]212号）

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以软材质量、颗粒质量、片剂质量等为评价指标,采用单因素法和Box-Behnken设计结合响应面法优化铁皮石斛超微粉泡腾片的处方。所得优化处方为:铁皮石斛超微粉44.5%、无水葡萄糖25%、碳酸氢钠15%和枸橼酸15%,以7%聚乙烯吡咯烷酮(PVP K30)的95%乙醇溶液为黏合剂湿法制粒,干燥至含水量小于3%,最后加硬脂酸镁0.5%,混匀后压片。所得泡腾片崩解时间为2.1 min,溶解后pH值为6.2。

The formulation of effervescent tablets loaded with micronized powder of Caulis Dendrobii officinalis was optimized by single factor experiment and Box-Behnken design combined with response surface methodology with the qualities of the damp mass, granules and tablets as indexes. The optimal formulation was as follows： micronized powder of Caulis Dendrobii officinalis 44.5 %, anhydrous glucose 25 %, sodium bicarbonate 15 %, citric acid 15% and magnesium stearate 0.5 %. The granules were prepared after adding 95 % ethanol containing 7 % polyvido...