期刊论文

中文

中国医药工业杂志

1001-8255

2018

49

1

38-44

10.16522/j.cnki.cjph.2018.01.003

国家自然科学基金项目面上项目

本校为第一机构

探讨两种或多种材料共修饰纳米载体的构建方法及其对体内体外靶向性的影响,并从其制剂学特性、修饰材料的选择及配合等方面进行分析。通过查阅近几年国内外文献,对两种配体结合类共修饰、配体结合类与细胞穿膜肽类共修饰、多糖类与配体结合类共修饰等不同类型的共修饰纳米载体进行了综合分析。两种或多种材料共修饰的方法具有显著提高纳米载体的稳定性、提高药物对细胞膜的穿透性和对靶点的精准性等优势。与单一材料修饰的纳米载体进行比较,共修饰纳米载体的优势更为明显。本文可为制备不同用途、类型纳米载体时合理选择修饰材料提供参考。

This paper discusses the construction methods of co-modified multi-functional nanocarriers, and the influence of two or more kinds of modification material on drug targeting in vitro and in vivo is analyzed in terms of formulation properties, selection and coordination of modified materials. On basis of the literature in recent 10 years, a comprehensive analysis for different types of co-modified nanocarriers was made, including the nanocarriers co-modified by two kinds of ligands, ligands and cell penetrating peptides （CPPs）, polysaccharides...