Intestinal bacteria-derived extracellular vesicles in metabolic dysfunction-associated steatotic liver disease: from mechanisms to therapeutics

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成果类型：

期刊论文

作者：

Qin, Li-Na;Yu, Yun-Feng;Ma, Lie;Yu, Rong

通讯作者：

Yu, R

作者机构：

[Yu, Yun-Feng; Qin, Li-Na; Yu, Rong; Yu, R] Hunan Univ Chinese Med, Dept Endocrinol, Hosp 1, Changsha, Hunan, Peoples R China.

[Ma, Lie] Henan Univ Chinese Med, Dept Reprod Med, Affiliated Hosp 3, Zhengzhou, Henan, Peoples R China.

[Yu, Rong; Yu, R] Hunan Univ Chinese Med, Coll Chinese Med, Changsha, Hunan, Peoples R China.

[Yu, Rong; Yu, R] Hunan Univ Chinese Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Yu, R ] H

Hunan Univ Chinese Med, Dept Endocrinol, Hosp 1, Changsha, Hunan, Peoples R China.

Hunan Univ Chinese Med, Coll Chinese Med, Changsha, Hunan, Peoples R China.

Hunan Univ Chinese Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Bacteria-derived extracellular vesicle (BEV);Intestinal microbiota;Metabolic dysfunction-associated steatotic liver disease (MASLD);Non-alcoholic fatty liver disease (NAFLD);Therapeutic applications

期刊：

MOLECULES AND CELLS

ISSN：

1016-8478

年：

2025

卷：

期：

页码：

100216

DOI：

10.1016/j.mocell.2025.100216

基金类别：

National Natural Science Foundation of China [U21A20411, 82074400]; Hunan Provincial Natural Science Foundation Innovation Research Group Project [2024JJ1007]; Hunan University of Chinese Medicine Disciplinary Construction "Revealing the List and Appointing Leaders" Project [22JBZ002]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disease that affects the health of approximately one-third of the world's population. It is the primary cause of end-stage liver disease, liver malignancy, and liver transplantation, resulting in a great medical burden. No medications have yet been approved by the US Food and Drug Administration (FDA) for treating MASLD without liver inflammation or scarring. Therefore, the development of specific drugs to treat MASLD remains a key task in the ongoing research objective. Extracellular vesicles (EVs) play an impor...

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Intestinal bacteria-derived extracellular vesicles in metabolic dysfunction-associated steatotic liver disease: from mechanisms to therapeutics

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