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Differential expression profiles of miRNA in granulomatous lobular mastitis and identification of possible biomarkers

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成果类型:
期刊论文
作者:
Ling, Jie;Xie, Xianmin;Wang, Yue;Huang, Weifang;Luo, Jun;...
作者机构:
[Luo, Jun; Ling, Jie; Huang, Weifang; Su, Jingqun] Hunan Univ Chinese Med, Grad Sch, Changsha, Hunan, Peoples R China.
[Xie, Xianmin] Hunan Univ Chinese Med, Dept Hand Surg, Hosp 1, Changsha, Hunan, Peoples R China.
[Wang, Yue; Liu, Lifang; Wu, Shiting; Fan, Hongqiao] Hunan Univ Chinese Med, Dept Galactophore, Hosp 1, Changsha, Hunan, Peoples R China.
[Liu, Lifang; Wu, Shiting] Hunan Univ Chinese Med, Dept Galactophore, Hosp 1, 95 Shaoshan Middle St, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
biomarker;gene expression profiles;granulomatous lobular mastitis;high-throughput sequencing;miRNA
期刊:
EXPERIMENTAL AND THERAPEUTIC MEDICINE
ISSN:
1792-0981
年:
2022
卷:
24
期:
2
页码:
500
机构署名:
本校为第一机构
院系归属:
第一中医临床学院
研究生院
摘要:
The etiology and pathogenesis of granulomatous lobular mastitis (GLM) remain largely elusive and the expression levels and regulatory roles of microRNAs (miRNAs or miRs) in GLM have remained mostly undetermined. In the present study, the miRNAs that were differentially expressed in breast biopsy samples from patients with GLM and normal tissue adjacent to fibroadenoma were analyzed, a comprehensive differential expression profile of miRNAs was provided and potential biomarkers were screened out. The expression profile of miRNAs was determined by high-throughput sequencing in the tissues of pat...

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