Gut microbiota characteristics in mice with antibiotic-associated diarrhea

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成果类型：

期刊论文

作者：

Shao, Haoqing;Zhang, Chenyang;Xiao, Nenqun;Tan, Zhoujin

通讯作者：

Tan, ZJ

作者机构：

[Zhang, Chenyang; Shao, Haoqing] Hunan Univ Chinese Med, Sch Tradit Chinese Med, Changsha, Hunan, Peoples R China.

[Zhang, Chenyang; Tan, Zhoujin; Shao, Haoqing] Hunan Key Lab TCM Prescript & Syndromes Translat, Changsha, Hunan, Peoples R China.

[Xiao, Nenqun] Hunan Univ Chinese Med, Sch Pharmaceut Sci, Changsha, Hunan, Peoples R China.

[Tan, Zhoujin] Hunan Univ Chinese Med, Sch Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Tan, ZJ ] H

Hunan Key Lab TCM Prescript & Syndromes Translat, Changsha, Hunan, Peoples R China.

Hunan Univ Chinese Med, Sch Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Gut microbiota;Antibiotic-associated diarrhea;Gentamicin;Cefradine;Enterococcus;Clostridium;16S rRNA gene sequencing

期刊：

BMC Microbiology

ISSN：

1471-2180

年：

2020

卷：

期：

页码：

1-9

DOI：

10.1186/s12866-020-01999-x

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (No: 81573951). The author of this paper was in charge of the project, and Professor Zhoujin Tan is the project leader. Funding body provided approval for the manuscript and had no role in design of the study, analysis and interpretation of data. Acknowledgements

机构署名：

本校为第一机构

院系归属：

医学院

药学院

摘要：

Antibiotic-associated diarrhea (AAD), defined as diarrhea that occurs in association with the administration of antibiotics and without another clear etiology, is one of the most common adverse drug events of antibiotics therapy. We established a diarrhea model induced by gentamycin and cefradine to investigate the microbiota characteristics in the intestinal lumen of mice with AAD and provide insights into noteworthy bacteria related to gentamicin and cefradine-associated diarrhea. The number of OTUs in the model group and the normal group was 983 and 2107, respectively, and 872 identical OTU...

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Gut microbiota characteristics in mice with antibiotic-associated diarrhea

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