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Lycium barbarum L. and Salvia miltiorrhiza Bunge protect retinal pigment epithelial cells through endoplasmic reticulum stress

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成果类型:
期刊论文
作者:
Ou, Chen;Xie, Wei;Jiang, Pengfei;Wang, Ying;Peng, Jun;...
通讯作者:
Houpan Song<&wdkj&>Qinghua Peng
作者机构:
[Jiang, Pengfei; Peng, Jun; Ou, Chen; Peng, Qinghua; Xie, Wei; Wang, Ying] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha 410007, Hunan, Peoples R China.
[Ou, Chen; Peng, Qinghua; Xie, Wei; Song, Houpan] Hunan Univ Chinese Med, Hunan Prov Key Lab TCM Diagnost, Changsha 410208, Hunan, Peoples R China.
[Jiang, Pengfei; Ou, Chen; Peng, Qinghua; Wang, Ying; Zhou, Yasha] Hunan Univ Chinese Med, Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Houpan Song] H
[Qinghua Peng] T
The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, 410007, China<&wdkj&>Hunan Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China<&wdkj&>Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China<&wdkj&>Hunan Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China
语种:
英文
关键词:
ARPE-19cells;Endoplasmic reticulum stress;Lycium barbarum L.;Retinal pigment epithelial cells;Salvia miltiorrhiza Bunge
期刊:
Journal of Ethnopharmacology
ISSN:
0378-8741
年:
2022
卷:
296
页码:
115519
基金类别:
Hunan Postgraduate Scientific Research Innovation Project [CX20210681]; Open Fund of Domestic First-class Discipline Construction Project of Hunan University of Chinese Medicine [2021ZYX01]; Hunan Engineering Technology Research Center for the Prevention and Treatment of Otorhinolaryngologic Diseases and Protection of Visual Function; Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine
机构署名:
本校为第一机构
院系归属:
第一中医临床学院
摘要:
ETHNOPHARMACOLOGICAL RELEVANCE: Lycium barbarum L. and Salvia miltiorrhiza Bunge (Gouqi and Danshen, LS) are traditional herbs for the treatment of retinal degeneration in China. LS have been integrated into pharmacopoeia and health care system of many countries around the world. However, the mechanisms by which LS protect retina are not fully clarified. AIM OF THE STUDY: We aimed at exploration of the effect of LS on retinal pigment epithelium (RPE) cells apoptosis as well as the endoplasmic reticulum (ER) stress mechanisms. MATERIAL AND METHO...

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