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Insights into the functional characteristics of rhubarb (Rheum officinale Baill) treatment on experimental traumatic brain injury through network pharmacology with metagenomics

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成果类型:
期刊论文
作者:
Fei Zheng;Xiaohang Guo;Wei Zhang;Yang Wang;En Hu;...
通讯作者:
Hong Su<&wdkj&>Changqing Deng
作者机构:
[Fei Zheng; Wei Zhang; Changqing Deng] The College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410208, P. R. China
[Xiaohang Guo] School of Medicine, Hunan University of Chinese Medicine, Changsha, 410208, P. R. China
[Yang Wang; En Hu] Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, 410008, P. R. China
The First Affiliated Hospital, Children's Medical Centre, Hengyang Medical School, University of South China, Hengyang, 421001, P. R. China
Discipline of Physiology, School of Medicine, University of Galway, H91 TK33, Ireland
通讯机构:
[Hong Su] I
[Changqing Deng] T
The College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410208, P. R. China<&wdkj&>Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, 410008, P. R. China<&wdkj&>Discipline of Physiology, School of Medicine, University of Galway, H91 TK33, Ireland<&wdkj&>Galway Neuroscience Centre, University of Galway, H91 TK33, Ireland
语种:
英文
期刊:
Phytomedicine
ISSN:
0944-7113
年:
2025
页码:
156853
基金类别:
Author contributions Fei Zheng: performed the methodology, software, validation, formal analysis, investigation, writing original draft, visualization and funding acquisition. Xiaohang Guo: performed the methodology, validation and editing. En Hu and Xin Guo: performed the conceptualization, validation, writing, review and editing. Wei Zhang: performed the resources, writing, review, editing and supervision. Yang Wang: conceptualization, writing, review, editing and supervision. Hong Su: performed the methodology, CRediT authorship contribution statement Fei Zheng: Writing – original draft, Visualization, Validation, Software, Methodology, Investigation, acquisition, Formal analysis. Xiaohang Guo: Writing – review & editing, Validation, Methodology. Wei Zhang: Writing – review & editing, Supervision, Resources. Yang Wang: Writing – review & editing, Supervision, Conceptualization. En Hu: Writing – review & editing, Validation, Conceptualization. Xin Guo: Writing – review & editing, Validation, Conceptualization. Hong Su: Validation, Acknowledgments This work was supported by the Hunan Provincial Natural Science Foundation of China ( 2023JJ30466 , 2024JJ6632 );the National Science Foundation for Post-doctoral Scientists of China ( 2022M711130 ); Excellent youth funding of Hunan Provincial Education Department ( 22B0365 ).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Background Traumatic brain injury (TBI) imposes a heavy burden on society and families owing to its high morbidity and mortality. Rhubarb has been noticed in the Chinese herb for treating TBI. The pharmacological effects include anti-inflammation, anti-bacterial, and purgative. But little is known about its potential mechanism when treating TBI. Traumatic brain injury (TBI) imposes a heavy burden on society and families owing to its high morbidity and mortality. Rhubarb has been noticed in the Chinese herb for treating TBI. The pharmacological ...

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