Irritable bowel syndrome is a common disease in gastrointestinal diseases, and its pathogenesis is closely related to intestinal mucosal barrier, gastrointestinal motility, visceral sensitivity, brain-gut-bacterial axis and so on. The intestinal mucosal mechanical barrier is the most important barrier for intestinal mucosa, and it has been studied comparatively in recent years. Intestinal mucosal mechanical barrier, Intestinal mucosal chemical barrier, intestinal mucosal biological barrier, intestinal mucosal immune barrier are consist of intestinal mucosal barrier, jointly resist bacterial en...