期刊论文

The Influence of Huluan Decoction on Serum Sex Hormones, Anti-mullerian hormone and inhibin B in Rats with Diminished Ovarian Reserve

中文

中国中医药现代远程教育

1672-2779

2019

17

12

92-94

10.3969/j.issn.1672-2779.2019.12.038

湖南省自然科学基金项目【No.2017JJ3243】 湖南中医药大学校级青年基金项目【No.DX201402】.

本校为第一机构

目的 观察中药护卵汤对卵巢储备功能减退(DOR)大鼠血清性激素及抗苗勒激素(AMH)、抑制素B(INHB)的影响.方法 选取动情周期为4～5d的雌性大鼠48只为实验动物,采用环磷酰胺(CTX)单次腹腔注射的方法制备DOR大鼠模型,以护卵汤为实验药物,以戊酸雌二醇为阳性对照药物,给药4周结束后检测各组大鼠血清性激素及AMH、INHB的变化.结果 与空白组相比,模型组大鼠血清中E2、P、AMH、INHB的含量均降低(P＜0.01),FSH、LH、T的含量均增高(P＜0.01);与模型组相比,护卵汤组和补佳乐组大鼠血清中E2、P、AMH、INHB的含量均增高(P＜0.05),FSH、LH、T的含量均降低(P＜0.01).结论 护卵汤对CTX所引起的DOR大鼠模型的卵巢...

Objective To observe the effects of Huluan decoction on serum sex hormones, anti-müllerian hormone (AMH) and inhibin B (INHB) in rats with diminished ovarian reserve (DOR). Methods 48 female rats with an estrous cycle of 4-5 days were selected as experimental animals, prepare the rat model of DOR by single intraperitoneal injection of cyclophosphamide, and taking Huluan decoction as experimental drug and estradiol valerate as positive control drug, then detect the changes of serum sex hormones, AMH and INHB in each group after the end of 4 wee...